SISTER STUDY RESEARCH

Comparing Breast Cancer Subtypes

Most papers looking at genetic risk factors for breast cancer compare genetic profiles of women with and without breast cancer. However, comparing genetic factors between women with different types of breast cancer may reveal differences in the causes of specific breast cancer subtypes. Results from a large pooled analysis that included Sister Study participants identified several potentially important genetic differences between Luminal A breast cancers (estrogen receptor [ER] positive and/or progesterone receptor [PR] positive and human epidermal growth factor receptor-2 [HER2] negative) and triple-negative breast cancers (ER-negative, PR-negative, HER2-negative). The authors used the results to develop genetic risk scores that may be useful for predicting breast cancer subtype.

Learn more here:
Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants that Confer Risk for Breast Cancer

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